(From the Paris Review. Link to the complete article given below)

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The story of Bulgakov’s Margarita is part of a long tradition, from Snow White’s wicked stepmother (who wanted to remain “fairest of them all”) to the Germanic legends that granted vigorous youth to men heroic enough to slay a dragon. There’s a spectacular example of youth enchantment in Ovid’s Metamorphoses when Jason defeats a dragon to get hold of a golden fleece, then implores his wife—the sorceress Medea—to rejuvenate his father, Aeson, using a potion of herbs so exotic they could have been taken from a modern cosmetics catalogue. In her dragon-harnessed chariot, Medea makes a tour of the most glamorous and outlandish sites in the Greek world in order to gather herbs. She fills twinned holes in the earth with the blood of a sacrificed sheep, adds wine and milk, then dips flaming torches in before setting them ablaze. Into a cauldron go roots from Thessaly, sands from Oceanus at the earth’s limit, and powdered rocks from the Far East.

Medea used a desiccated old olive wand to stir the brew; as she did so, it sprouted leaves, then grew heavy with olives. Spatters from the broth caused flowers and grass to spring up on the cold dark earth. At this final sign, Medea felt ready to proceed: she slit Aeson’s jugular veins and poured in her potion. “Quickly his beard and his hair lost their whiteness … New flesh filled out his sagging wrinkles, and his limbs grew young and strong. The old king marveled at the change in himself, recalling that this was the Aeson of forty years ago.”

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The earliest known text concerned with the elixirs of youth is an early Chinese commentary on the I Ching, the “Book of Changes,” in which chemical substances and processes are tentatively correlated with the book’s famous hexagrams. The I Ching takes for granted that the universe and all beings in it are caught up in cycles of transformation and suggests that the astute application of mystical and medical knowledge can influence those changes for the better.

In Europe, alchemists were obsessed with generating gold, but in China, they preferred to work on youth elixirs. A string of Chinese alchemists claimed to have created a rejuvenating potion; Joseph Needham, the historian, scientist, and Sinologist, was so struck by the frequency with which Chinese emperors were poisoned by these drugs that he tabulated a list of victims. In around 300 A.D., a Chinese alchemist called Ge Hong collated various recipes. Three centuries later, a more detailed treatise specified the inclusion of obscure, exotic substances such as mercurial salts and compounds of sulfur. There are more than a thousand different names for these potions, most of which carried the same basic mineral ingredients.

One of Ge Hong’s near contemporaries in the West, a Byzantine called Synesius, believed that the physical transformations effected by alchemy were less important than the mental positions adopted by its practitioners. A true alchemy of youth didn’t require a laboratory or precious exotic substances; all that was needed was the right kind of incantation and a change in attitude.

Read more at this link from the Paris Review